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Genes 2018, 9(1), 29; https://doi.org/10.3390/genes9010029

The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer

1
Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA
2
Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Sciences, Northwest University, Xi’an 710069, Shaanxi, China
3
Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
*
Author to whom correspondence should be addressed.
Received: 7 November 2017 / Revised: 21 December 2017 / Accepted: 4 January 2018 / Published: 10 January 2018
(This article belongs to the Special Issue Non-coding RNAs)
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Abstract

Triple-negative breast cancer (TNBC) is an operational term for breast cancers lacking targetable estrogen receptor expression and HER2 amplifications. TNBC is, therefore, inherently heterogeneous, and is associated with worse prognosis, greater rates of metastasis, and earlier onset. TNBC displays mutational and transcriptional diversity, and distinct mRNA transcriptional subtypes exhibiting unique biology. High-throughput sequencing has extended cancer research far beyond protein coding regions that include non-coding small RNAs, such as miRNA, isomiR, tRNA, snoRNAs, snRNA, yRNA, 7SL, and 7SK. In this study, we performed small RNA profiling of 26 TNBC cell lines, and compared the abundance of non-coding RNAs among the transcriptional subtypes of triple negative breast cancer. We also examined their co-expression pattern with corresponding mRNAs. This study provides a detailed description of small RNA expression in triple-negative breast cancer cell lines that can aid in the development of future biomarker and novel targeted therapies. View Full-Text
Keywords: small RNA; miRNA; TNBCtype; biomarker small RNA; miRNA; TNBCtype; biomarker
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Guo, Y.; Yu, H.; Wang, J.; Sheng, Q.; Zhao, S.; Zhao, Y.-Y.; Lehmann, B.D. The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer. Genes 2018, 9, 29.

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