The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer
AbstractTriple-negative breast cancer (TNBC) is an operational term for breast cancers lacking targetable estrogen receptor expression and HER2 amplifications. TNBC is, therefore, inherently heterogeneous, and is associated with worse prognosis, greater rates of metastasis, and earlier onset. TNBC displays mutational and transcriptional diversity, and distinct mRNA transcriptional subtypes exhibiting unique biology. High-throughput sequencing has extended cancer research far beyond protein coding regions that include non-coding small RNAs, such as miRNA, isomiR, tRNA, snoRNAs, snRNA, yRNA, 7SL, and 7SK. In this study, we performed small RNA profiling of 26 TNBC cell lines, and compared the abundance of non-coding RNAs among the transcriptional subtypes of triple negative breast cancer. We also examined their co-expression pattern with corresponding mRNAs. This study provides a detailed description of small RNA expression in triple-negative breast cancer cell lines that can aid in the development of future biomarker and novel targeted therapies. View Full-Text
- Supplementary File 1:
Supplementary (ZIP, 5146 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Guo, Y.; Yu, H.; Wang, J.; Sheng, Q.; Zhao, S.; Zhao, Y.-Y.; Lehmann, B.D. The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer. Genes 2018, 9, 29.
Guo Y, Yu H, Wang J, Sheng Q, Zhao S, Zhao Y-Y, Lehmann BD. The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer. Genes. 2018; 9(1):29.Chicago/Turabian Style
Guo, Yan; Yu, Hui; Wang, Jing; Sheng, Quanhu; Zhao, Shilin; Zhao, Ying-Yong; Lehmann, Brian D. 2018. "The Landscape of Small Non-Coding RNAs in Triple-Negative Breast Cancer." Genes 9, no. 1: 29.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.