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Genes 2018, 9(2), 65; doi:10.3390/genes9020065

lncRNA Gene Signatures for Prediction of Breast Cancer Intrinsic Subtypes and Prognosis

Department of Computer and Information Science, University of Mississippi, Oxford, MS 38677, USA
Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 20025, China
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA
Department of Data Science, John D. Bower School of Population Health, University of Mississippi Medical Center, Jackson, MS 39216, USA
Author to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 23 December 2017 / Accepted: 15 January 2018 / Published: 26 January 2018
(This article belongs to the Special Issue Non-coding RNAs)
View Full-Text   |   Download PDF [978 KB, uploaded 26 January 2018]   |  


Background: Breast cancer is intrinsically heterogeneous and is commonly classified into four main subtypes associated with distinct biological features and clinical outcomes. However, currently available data resources and methods are limited in identifying molecular subtyping on protein-coding genes, and little is known about the roles of long non-coding RNAs (lncRNAs), which occupies 98% of the whole genome. lncRNAs may also play important roles in subgrouping cancer patients and are associated with clinical phenotypes. Methods: The purpose of this project was to identify lncRNA gene signatures that are associated with breast cancer subtypes and clinical outcomes. We identified lncRNA gene signatures from The Cancer Genome Atlas (TCGA )RNAseq data that are associated with breast cancer subtypes by an optimized 1-Norm SVM feature selection algorithm. We evaluated the prognostic performance of these gene signatures with a semi-supervised principal component (superPC) method. Results: Although lncRNAs can independently predict breast cancer subtypes with satisfactory accuracy, a combined gene signature including both coding and non-coding genes will give the best clinically relevant prediction performance. We highlighted eight potential biomarkers (three from coding genes and five from non-coding genes) that are significantly associated with survival outcomes. Conclusion: Our proposed methods are a novel means of identifying subtype-specific coding and non-coding potential biomarkers that are both clinically relevant and biologically significant. View Full-Text
Keywords: lncRNA; intrinsic subtypes; feature selection; breast cancer lncRNA; intrinsic subtypes; feature selection; breast cancer

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Zhang, S.; Wang, J.; Ghoshal, T.; Wilkins, D.; Mo, Y.-Y.; Chen, Y.; Zhou, Y. lncRNA Gene Signatures for Prediction of Breast Cancer Intrinsic Subtypes and Prognosis. Genes 2018, 9, 65.

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