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Genes 2017, 8(7), 189; doi:10.3390/genes8070189

Developmental Expression of HSP60 and HSP10 in the Coilia nasus Testis during Upstream Spawning Migration

Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Shanshui Road 9, Wuxi 214000, Jiangsu, China
Scientific Observing and Experimental Station of Fishery Resources and Environment in the Lower Reaches of the Yangtze River, Ministry of Agriculture, Xuejiali 69, Wuxi 214000, Jiangsu, China
Author to whom correspondence should be addressed.
Academic Editor: Paolo Cinelli
Received: 2 June 2017 / Revised: 17 July 2017 / Accepted: 19 July 2017 / Published: 21 July 2017
(This article belongs to the Section Molecular Genetics)
View Full-Text   |   Download PDF [6367 KB, uploaded 25 July 2017]   |  


Heat shock protein 60 (HSP60) and heat shock protein 10 (HSP10) are important chaperones, which have been proven to have essential roles in mediating the correct folding of nuclear encoded proteins imported to mitochondria. Mitochondria are known as the power house of the cell, with which it produces energy and respires aerobically. In this regard, the obtained HSP60 and HSP10 have typical characteristics of the HSP60/10 family signature. Their mRNA transcripts detected were highest during the developmental phase (in April), while the lowest levels were found in the resting phase (after spawning in late July). Additionally, the strongest immunolabeling positive signals were found in the primary spermatocyte, with lower positive staining in secondary sperm cells, and a weak or absent level in the mature sperm. At the electron microscopic level, immunogold particles were localized in the mitochondrial matrix. Data indicated that HSP10 and HSP60 were inducible and functional in the Coilia nasus testis development and migration process, suggesting their essential roles in this process. The results also indicated that HSP60 may be one indicator of properly working mitochondrial import and refolding in the fish testis. This study also provides an expanded perspective on the role of heat shock protein families in spawning migration biology. View Full-Text
Keywords: Coilia nasus; Spawning Migration; Heat shock protein 60; Heat shock protein 10 Coilia nasus; Spawning Migration; Heat shock protein 60; Heat shock protein 10

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fang, D.-A.; Zhou, Y.-F.; Zhang, M.-Y.; Xu, D.-P.; Liu, K.; Duan, J.-R. Developmental Expression of HSP60 and HSP10 in the Coilia nasus Testis during Upstream Spawning Migration. Genes 2017, 8, 189.

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