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Role of MYC in B Cell Lymphomagenesis
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Genes 2017, 8(4), 116; doi:10.3390/genes8040116

The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects

1
Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
2
Cytogenetics Laboratory, Laboratory Corporation of America, Research Triangle Park, NC 27709, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Received: 13 January 2017 / Revised: 27 March 2017 / Accepted: 27 March 2017 / Published: 5 April 2017
(This article belongs to the Special Issue MYC Networks)
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Abstract

c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dysregulation induces lymphomagenesis by loss of the tight control of c-MYC expression, leading to overexpression of intact c-MYC protein, in contrast to the somatic mutations or fusion proteins seen in many other oncogenes. Dysregulation of c-MYC in B-cell lymphomas occurs either as a primary event in Burkitt lymphoma, or secondarily in aggressive lymphomas such as diffuse large B-cell lymphoma, plasmablastic lymphoma, mantle cell lymphoma, or double-hit lymphoma. Secondary c-MYC changes include gene translocation and gene amplification, occurring against a background of complex karyotype, and most often confer aggressive clinical behavior, as evidenced in the double-hit lymphomas. In low-grade B-cell lymphomas, acquisition of c-MYC rearrangement usually results in transformation into highly aggressive lymphomas, with some exceptions. In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on prognosis and diagnosis in specific types of B-cell lymphoma. View Full-Text
Keywords: c-MYC; lymphoma; diffuse large B-cell lymphoma; plasmablastic lymphoma; mantle cell lymphoma; double-hit lymphoma; complex karyotype c-MYC; lymphoma; diffuse large B-cell lymphoma; plasmablastic lymphoma; mantle cell lymphoma; double-hit lymphoma; complex karyotype
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nguyen, L.; Papenhausen, P.; Shao, H. The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects. Genes 2017, 8, 116.

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