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Genes 2017, 8(4), 115; doi:10.3390/genes8040115

Role of MYC in B Cell Lymphomagenesis

1
Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia
2
Department of Pathology and Cytology, University Hospital Center Zagreb, 10000 Zagreb, Croatia
3
Institute for Anthropological Research, Gajeva 32, 10000 Zagreb, Croatia
4
Medical School Zagreb, University of Zagreb, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Received: 30 January 2017 / Revised: 20 March 2017 / Accepted: 28 March 2017 / Published: 4 April 2017
(This article belongs to the Special Issue MYC Networks)
View Full-Text   |   Download PDF [1297 KB, uploaded 25 April 2017]   |  

Abstract

B cell lymphomas mainly arise from different developmental stages of B cells in germinal centers of secondary lymphoid tissue. There are a number of signaling pathways that affect the initiation and development of B cell lymphomagenesis. The functions of several key proteins that represent branching points of signaling networks are changed because of their aberrant expression, degradation, and/or accumulation, and those events determine the fate of the affected B cells. One of the most influential transcription factors, commonly associated with unfavorable prognosis for patients with B cell lymphoma, is nuclear phosphoprotein MYC. During B cell lymphomagenesis, oncogenic MYC variant is deregulated through various mechanisms, such as gene translocation, gene amplification, and epigenetic deregulation of its expression. Owing to alterations of downstream signaling cascades, MYC-overexpressing neoplastic B cells proliferate rapidly, avoid apoptosis, and become unresponsive to most conventional treatments. This review will summarize the roles of MYC in B cell development and oncogenesis, as well as its significance for current B cell lymphoma classification. We compared communication networks within transformed B cells in different lymphomas affected by overexpressed MYC and conducted a meta-analysis concerning the association of MYC with tumor prognosis in different patient populations. View Full-Text
Keywords: MYC; B cell; lymphoma; signaling pathways; prognostic factor; meta-analysis MYC; B cell; lymphoma; signaling pathways; prognostic factor; meta-analysis
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MDPI and ACS Style

Korać, P.; Dotlić, S.; Matulić, M.; Zajc Petranović, M.; Dominis, M. Role of MYC in B Cell Lymphomagenesis. Genes 2017, 8, 115.

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