MNT and Emerging Concepts of MNT‐MYC Antagonism
AbstractMYC family proteins play fundamental roles in stem and progenitor cell homeostasis, morphogenesis and cancer. As expected for proteins that profoundly affect the fate of cells, the activities of MYC are regulated at a multitude of levels. One mechanism with the potential to broadly affect the activities of MYC is transcriptional antagonism by a group of MYC‐related transcriptional repressors. From this group, the protein MNT has emerged as having perhaps the most far‐reaching impact on MYC activities. In this review, we discuss the current understanding of MNT, its regulation and how, as a MYC antagonist, it functions both as a tumor suppressor and facilitator of MYC‐driven proliferation and oncogenesis. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Yang, G.; Hurlin, P.J. MNT and Emerging Concepts of MNT‐MYC Antagonism. Genes 2017, 8, 83.
Yang G, Hurlin PJ. MNT and Emerging Concepts of MNT‐MYC Antagonism. Genes. 2017; 8(2):83.Chicago/Turabian Style
Yang, Guang; Hurlin, Peter J. 2017. "MNT and Emerging Concepts of MNT‐MYC Antagonism." Genes 8, no. 2: 83.