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Genes 2017, 8(2), 83; doi:10.3390/genes8020083

MNT and Emerging Concepts of MNT‐MYC Antagonism

Shriners Hospitals for Children Research Center, Portland, OR 97239, USA
Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, 97239, USA
Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA
Author to whom correspondence should be addressed.
Received: 9 January 2017 / Accepted: 16 February 2017 / Published: 20 February 2017
(This article belongs to the Special Issue MYC Networks)
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MYC family proteins play fundamental roles in stem and progenitor cell homeostasis, morphogenesis and cancer. As expected for proteins that profoundly affect the fate of cells, the activities of MYC are regulated at a multitude of levels. One mechanism with the potential to broadly affect the activities of MYC is transcriptional antagonism by a group of MYC‐related transcriptional repressors. From this group, the protein MNT has emerged as having perhaps the most far‐reaching impact on MYC activities. In this review, we discuss the current understanding of MNT, its regulation and how, as a MYC antagonist, it functions both as a tumor suppressor and facilitator of MYC‐driven proliferation and oncogenesis. View Full-Text
Keywords: MNT; MYC; MAX; MLX; MXD; MLXIP; MYC antagonism MNT; MYC; MAX; MLX; MXD; MLXIP; MYC antagonism

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, G.; Hurlin, P.J. MNT and Emerging Concepts of MNT‐MYC Antagonism. Genes 2017, 8, 83.

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