Next Article in Journal
Epigenetics in Stroke Recovery
Next Article in Special Issue
c‐Myc‐Induced Survivin Is Essential for Promoting  the Notch‐Dependent T Cell Differentiation from  Hematopoietic Stem Cells
Previous Article in Journal
Historical and Clinical Experiences of Gene Therapy for Solid Cancers in China
Previous Article in Special Issue
MNT and Emerging Concepts of MNT‐MYC Antagonism
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Genes 2017, 8(3), 88; doi:10.3390/genes8030088

MYC in Regulating Immunity: Metabolism and Beyond

Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, The Research Institute at Nationwide Children’s Hospital, Ohio State University, Columbus, OH 43205, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Received: 1 January 2017 / Revised: 9 February 2017 / Accepted: 16 February 2017 / Published: 25 February 2017
(This article belongs to the Special Issue MYC Networks)
View Full-Text   |   Download PDF [1058 KB, uploaded 25 February 2017]   |  

Abstract

Myelocytomatosis oncogene (MYC) family members, including cellular MYC (c-Myc), neuroblastoma derived MYC (MYCN), and lung carcinoma derived MYC (MYCL), have all been implicated as key oncogenic drivers in a broad range of human cancers. Beyond cancer, MYC plays an important role in other physiological and pathological processes, namely immunity and immunological diseases. MYC largely functions as a transcription factor that promotes the expression of numerous target genes to coordinate death, proliferation, and metabolism at the cellular, tissue, and organismal levels. It has been shown that the expression of MYC family members is tightly regulated in immune cells during development or upon immune stimulations. Emerging evidence suggests that MYC family members play essential roles in regulating the development, differentiation and activation of immune cells. Through driving the expression of a broad range of metabolic genes in immune cells, MYC family members coordinate metabolic programs to support immune functions. Here, we discuss our understanding of MYC biology in immune system and how modulation of MYC impacts immune metabolism and responses. View Full-Text
Keywords: MYC; immunity; metabolism MYC; immunity; metabolism
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gnanaprakasam, J.R.; Wang, R. MYC in Regulating Immunity: Metabolism and Beyond. Genes 2017, 8, 88.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top