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Genes 2017, 8(2), 48; doi:10.3390/genes8020048

Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases

1
Department of Vertebrate Zoology, Faculty of Biology, Saint Petersburg State University, Universitetskaya nab., 7/9, Saint Petersburg 199034, Russia
2
Laboratory of Molecular Neurobiology, Department of Ecological Physiology, Institute of Experimental Medicine, ul. Akad. Pavlov, 12, Saint Petersburg 197376, Russia
Current address: Laboratory of General Immunology, Department of Immunology, Institute of Experimental Medicine, ul. Akad. Pavlov, 12, Saint Petersburg 197376, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Xiangning (Sam) Chen
Received: 27 September 2016 / Revised: 21 December 2016 / Accepted: 19 January 2017 / Published: 25 January 2017
(This article belongs to the Special Issue Genetic Mechanism of Psychiatric Disorders)
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Abstract

Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates. At the same time, some neuropsychiatric disorders, such as schizophrenia, autism, bipolar disorder, and dyslexia, are known to be associated with lateralization failure. In this review, we consider possible links in the mechanisms of determination of visceral asymmetry and brain lateralization, through cilia. We review the functions of seven genes associated with both cilia, and with neurodevelopmental diseases, keeping in mind their possible role in the establishment of the left-right brain asymmetry. View Full-Text
Keywords: schizophrenia; centrosome; left-right asymmetry; Disc1; PCM-1; pericentrin; abelson helper integrator 1; hamartin; DCDC2; Dyx1c1 schizophrenia; centrosome; left-right asymmetry; Disc1; PCM-1; pericentrin; abelson helper integrator 1; hamartin; DCDC2; Dyx1c1
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Trulioff, A.; Ermakov, A.; Malashichev, Y. Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases. Genes 2017, 8, 48.

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