The Future is The Past: Methylation QTLs in Schizophrenia
AbstractGenome-wide association studies (GWAS) have remarkably advanced insight into the genetic basis of schizophrenia (SCZ). Still, most of the functional variance in disease risk remains unexplained. Hence, there is a growing need to map genetic variability-to-genes-to-functions for understanding the pathophysiology of SCZ and the development of better treatments. Genetic variation can regulate various cellular functions including DNA methylation, an epigenetic mark with important roles in transcription and the mediation of environmental influences. Methylation quantitative trait loci (meQTLs) are derived by mapping levels of DNA methylation in genetically different, genotyped individuals and define loci at which DNA methylation is influenced by genetic variation. Recent evidence points to an abundance of meQTLs in brain tissues whose functional contributions to development and mental diseases are still poorly understood. Interestingly, fetal meQTLs reside in regulatory domains affecting methylome reconfiguration during early brain development and are enriched in loci identified by GWAS for SCZ. Moreover, fetal meQTLs are preserved in the adult brain and could trace early epigenomic deregulation during vulnerable periods. Overall, these findings highlight the role of fetal meQTLs in the genetic risk for and in the possible neurodevelopmental origin of SCZ. View Full-Text
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Hoffmann, A.; Ziller, M.; Spengler, D. The Future is The Past: Methylation QTLs in Schizophrenia. Genes 2016, 7, 104.
Hoffmann A, Ziller M, Spengler D. The Future is The Past: Methylation QTLs in Schizophrenia. Genes. 2016; 7(12):104.Chicago/Turabian Style
Hoffmann, Anke; Ziller, Michael; Spengler, Dietmar. 2016. "The Future is The Past: Methylation QTLs in Schizophrenia." Genes 7, no. 12: 104.
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