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Genes 2017, 8(12), 365; doi:10.3390/genes8120365

Genome-Wide Comprehensive Analysis the Molecular Phylogenetic Evaluation and Tissue-Specific Expression of SABATH Gene Family in Salvia miltiorrhiza

1,2,†
,
1,†
and
1,*
1
National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi’an 710119, China
2
College of Chemistry, Biology and Materials Science, East China University of Technology, Nanchang 330013, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 22 September 2017 / Revised: 16 November 2017 / Accepted: 28 November 2017 / Published: 5 December 2017
(This article belongs to the Section Plant Genetics and Genomics)
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Abstract

The plant SABATH gene family is a group of O-methyltransferases (O-MTs), which belongs to the S-adenosyl-l-methionine-dependent methyltransferases (SAM-MTs). The resulting reaction products of SABATH genes play an important role in various processes of plant development. In this study, a total of 30 SABATH genes were detected in Salvia miltiorrhiza, which is an important medicinal plant, widely used to treat cardiovascular disease. Multiple sequence alignment and phylogenetic analyses showed that SmSABATH genes could be classified into three groups. The ratios of non-synonymous (Ka) and synonymous (Ks) substitution rates of 11 pairs paralogous of SmSABATH genes revealed that the SmSABATH genes had gone through purifying selection. Positive selection analyses using site models and branch-site models indicated that SmSABATH genes had undergone selective pressure for adaptive evolution. Functional divergence analyses suggested that the SmSABATH subgroup genes were divergent in terms of functions and positive selection sites that contributed to a functional divergence among the subgroups that were detected. Tissue-specific expression showed that the SABATH gene family in S. miltiorrhiza was primarily expressed in stems and leaves. View Full-Text
Keywords: SABATH gene family; phylogenetic analysis; conserved motifs; nonsynonymous and synonymous substitution rate; positive selection; functional divergence; tissue-specific expression SABATH gene family; phylogenetic analysis; conserved motifs; nonsynonymous and synonymous substitution rate; positive selection; functional divergence; tissue-specific expression
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, B.; Wang, S.; Wang, Z. Genome-Wide Comprehensive Analysis the Molecular Phylogenetic Evaluation and Tissue-Specific Expression of SABATH Gene Family in Salvia miltiorrhiza. Genes 2017, 8, 365.

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