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Genes 2017, 8(12), 351; doi:10.3390/genes8120351

Evolution of Tandem Repeat Satellite Sequences in Two Closely Related Caenorhabditis Species. Diminution of Satellites in Hermaphrodites

1
Department of Computer Science, Universitat Politècnica de Catalunya, Jordi Girona 1-3, 08034 Barcelona, Spain
2
Evolutionary Genomics Group, Research Program on Biomedical Informatics (GRIB)—Hospital del Mar Research Institute (IMIM), Universitat Pompeu Fabra (UPF), Doctor Aiguader 86, 08003 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Received: 17 October 2017 / Revised: 13 November 2017 / Accepted: 15 November 2017 / Published: 28 November 2017
(This article belongs to the Section Population and Evolutionary Genetics and Genomics)
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Abstract

The availability of the genome sequence of the unisexual (male-female) Caenorhabditis nigoni offers an opportunity to compare its non-coding features with the related hermaphroditic species Caenorhabditis briggsae; to understand the evolutionary dynamics of their tandem repeat sequences (satellites), as a result of evolution from the unisexual ancestor. We take advantage of the previously developed SATFIND program to build satellite families defined by a consensus sequence. The relative number of satellites (satellites/Mb) in C. nigoni is 24.6% larger than in C. briggsae. Some satellites in C. nigoni have developed from a proto-repeat present in the ancestor species and are conserved as an isolated sequence in C. briggsae. We also identify unique satellites which occur only once and joint satellite families with a related sequence in both species. Some of these families are only found in C. nigoni, which indicates a recent appearance; they contain conserved adjacent 5′ and 3′ regions, which may favor transposition. Our results show that the number, length and turnover of satellites are restricted in the hermaphrodite C. briggsae when compared with the unisexual C. nigoni. We hypothesize that this results from differences in unequal recombination during meiotic chromosome pairing, which limits satellite turnover in hermaphrodites. View Full-Text
Keywords: satellite DNA; tandem repeat sequences; Caenorhabditis nigoni; Caenorhabditis briggssae; hermaphroditism; nematodes satellite DNA; tandem repeat sequences; Caenorhabditis nigoni; Caenorhabditis briggssae; hermaphroditism; nematodes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Subirana, J.A.; Messeguer, X. Evolution of Tandem Repeat Satellite Sequences in Two Closely Related Caenorhabditis Species. Diminution of Satellites in Hermaphrodites. Genes 2017, 8, 351.

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