Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases
AbstractDNA replication is constantly challenged by DNA lesions, noncanonical DNA structures and difficult-to-replicate DNA sequences. Two major strategies to rescue a stalled replication fork and to ensure continuous DNA synthesis are: (1) template switching and recombination-dependent DNA synthesis; and (2) translesion synthesis (TLS) using specialized DNA polymerases to perform nucleotide incorporation opposite DNA lesions. The former pathway is mainly error-free, and the latter is error-prone and a major source of mutagenesis. An accepted model of translesion synthesis involves DNA polymerase switching steps between a replicative DNA polymerase and one or more TLS DNA polymerases. The mechanisms that govern the selection and exchange of specialized DNA polymerases for a given DNA lesion are not well understood. In this review, recent studies concerning the mechanisms of selection and switching of DNA polymerases in eukaryotic systems are summarized.
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Zhao, L.; Washington, M.T. Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases. Genes 2017, 8, 24.
Zhao L, Washington MT. Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases. Genes. 2017; 8(1):24.Chicago/Turabian Style
Zhao, Linlin; Washington, M. T. 2017. "Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases." Genes 8, no. 1: 24.
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