Super Enhancers in Cancers, Complex Disease, and Developmental Disorders
AbstractRecently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation. While their functions are not completely understood, it is clear that these regions driving high-level transcription are susceptible to perturbation, and trait-associated single nucleotide polymorphisms (SNPs) occur within super-enhancers of disease-relevant cell types. Here we review evidence for super-enhancer involvement in cancers, complex diseases, and developmental disorders and discuss interactions between super-enhancers and cofactors/chromatin regulators. View Full-Text
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Niederriter, A.R.; Varshney, A.; Parker, S.C.J.; Martin, D.M. Super Enhancers in Cancers, Complex Disease, and Developmental Disorders. Genes 2015, 6, 1183-1200.
Niederriter AR, Varshney A, Parker SCJ, Martin DM. Super Enhancers in Cancers, Complex Disease, and Developmental Disorders. Genes. 2015; 6(4):1183-1200.Chicago/Turabian Style
Niederriter, Adrienne R.; Varshney, Arushi; Parker, Stephen C.J.; Martin, Donna M. 2015. "Super Enhancers in Cancers, Complex Disease, and Developmental Disorders." Genes 6, no. 4: 1183-1200.