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Genes 2015, 6(3), 672-684; doi:10.3390/genes6030672

Complete Genomic Characterization of Porcine Reproductive and Respiratory Syndrome Virus Strain HB-XL

1,2
,
1,2,* and 1,2,*
1
College of Animal Medicine, Agriculture University of Hebei, Baoding 071001, China
2
Hebei Engineering and Technology Research Center of Veterinary Biotechnology, Baoding 071001, China
*
Authors to whom correspondence should be addressed.
Academic Editor: J. Peter W. Young
Received: 18 May 2015 / Revised: 12 July 2015 / Accepted: 13 July 2015 / Published: 23 July 2015
View Full-Text   |   Download PDF [428 KB, uploaded 23 July 2015]   |  

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is the causal agent of a serious disease of swine. Here, we report the genome sequence of PRRSV strain HB-XL isolated from a pig farm with a clinical outbreak of porcine reproductive and respiratory syndrome. The genome is 15,323 bp long and has nine open reading frames (GenBank: KP162169). Comparative and phylogenetic analysis showed that HB-XL belongs to the highly pathogenic PRRSV (HP-PRRSV) subfamily in the family PRRSV. The viral nonstructural protein 2 (Nsp2) of the HB-XL strain contained 30 discontinuous amino acid (AA) deletions relative to that of the Nsp2 of the VR2332 strain. The AA substitutions R13 and R151 suggested high virulence of the HB-XL strain. The unique mutations in glycoprotein 5 (GP5) and Nsp2 revealed that HB-XL might be a novel variant PRRSV strain recombined with vaccine strains. However, the low morbidity and mortality in the pig herd from which HB-XL was isolated indicate that the virulence of the virus was weak, so it has potential as a future vaccine strain. View Full-Text
Keywords: porcine reproductive and respiratory syndrome virus; Nsp2; GP5; variation analysis porcine reproductive and respiratory syndrome virus; Nsp2; GP5; variation analysis
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MDPI and ACS Style

Zuo, Y.; Yuan, W.; Sun, J. Complete Genomic Characterization of Porcine Reproductive and Respiratory Syndrome Virus Strain HB-XL. Genes 2015, 6, 672-684.

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