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Genes 2015, 6(3), 662-671; doi:10.3390/genes6030662

Adaptive Evolution of CENP-A in Percid Fishes

Department of Biology, University of West Georgia, Carrollton, GA 30118, USA
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Author to whom correspondence should be addressed.
Academic Editor: J. Peter W. Young
Received: 27 May 2015 / Revised: 7 July 2015 / Accepted: 9 July 2015 / Published: 17 July 2015
(This article belongs to the Section Population and Evolutionary Genetics and Genomics)
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Abstract

Centromeric protein A (CENP-A) is the epigenetic determinant of centromeres. This protein has been shown to be adaptively evolving in a number of animal and plant species. In a previous communication we were able to demonstrate that signs of adaptive evolution were detected in the comparison of CENP-A sequences from three percid fish species. In this study we isolated the CENP-A gene from eight additional species from the Percidae family. With these sequences and those previously obtained, we carried out a more robust statistical analysis of codon specific positive selection in CENP-A coding sequences of eleven percid species. We were able to demonstrate that at least two amino acid positions within the N-terminal tail are under strong positive selection and that one of these positions is potentially a substrate for phosphorylation. While nonsynonymous substitutions were detected in the histone fold domain, these were not statistically supported as resulting from positive selection. View Full-Text
Keywords: CENP-A; adaptive evolution; percids; fishes CENP-A; adaptive evolution; percids; fishes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Abbey, H.N.A.; Kral, L.G. Adaptive Evolution of CENP-A in Percid Fishes. Genes 2015, 6, 662-671.

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