Adaptive Evolution of CENP-A in Percid Fishes
AbstractCentromeric protein A (CENP-A) is the epigenetic determinant of centromeres. This protein has been shown to be adaptively evolving in a number of animal and plant species. In a previous communication we were able to demonstrate that signs of adaptive evolution were detected in the comparison of CENP-A sequences from three percid fish species. In this study we isolated the CENP-A gene from eight additional species from the Percidae family. With these sequences and those previously obtained, we carried out a more robust statistical analysis of codon specific positive selection in CENP-A coding sequences of eleven percid species. We were able to demonstrate that at least two amino acid positions within the N-terminal tail are under strong positive selection and that one of these positions is potentially a substrate for phosphorylation. While nonsynonymous substitutions were detected in the histone fold domain, these were not statistically supported as resulting from positive selection. View Full-Text
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Abbey, H.N.A.; Kral, L.G. Adaptive Evolution of CENP-A in Percid Fishes. Genes 2015, 6, 662-671.
Abbey HNA, Kral LG. Adaptive Evolution of CENP-A in Percid Fishes. Genes. 2015; 6(3):662-671.Chicago/Turabian Style
Abbey, Harriet N.A.; Kral, Leos G. 2015. "Adaptive Evolution of CENP-A in Percid Fishes." Genes 6, no. 3: 662-671.