Next Article in Journal
The Revolution in Human Monogenic Disease Mapping
Next Article in Special Issue
Sumoylation is Required for the Cytoplasmic Accumulation of a Subset of mRNAs
Previous Article in Journal
A Balanced Look at the Implications of Genomic (and Other “Omics”) Testing for Disease Diagnosis and Clinical Care
Article Menu

Export Article

Open AccessReview
Genes 2014, 5(3), 767-791; doi:10.3390/genes5030767

Regulation of mRNA Trafficking by Nuclear Pore Complexes

Institut Jacques Monod, CNRS, UMR 7592, University Paris Diderot, Sorbonne Paris Cité, Paris F-75205, France
*
Author to whom correspondence should be addressed.
Received: 25 July 2014 / Revised: 25 August 2014 / Accepted: 26 August 2014 / Published: 2 September 2014
(This article belongs to the Special Issue Mechanisms of mRNA Nuclear Export)
View Full-Text   |   Download PDF [10614 KB, uploaded 2 September 2014]   |  

Abstract

Over the last two decades, multiple studies have explored the mechanisms governing mRNA export out of the nucleus, a crucial step in eukaryotic gene expression. During transcription and processing, mRNAs are assembled into messenger ribonucleoparticles (mRNPs). mRNPs are then exported through nuclear pore complexes (NPCs), which are large multiprotein assemblies made of several copies of a limited number of nucleoporins. A considerable effort has been put into the dissection of mRNA export through NPCs at both cellular and molecular levels, revealing the conserved contributions of a subset of nucleoporins in this process, from yeast to vertebrates. Several reports have also demonstrated the ability of NPCs to sort out properly-processed mRNPs for entry into the nuclear export pathway. Importantly, changes in mRNA export have been associated with post-translational modifications of nucleoporins or changes in NPC composition, depending on cell cycle progression, development or exposure to stress. How NPC modifications also impact on cellular mRNA export in disease situations, notably upon viral infection, is discussed. View Full-Text
Keywords: mRNA export; mRNA quality control; nuclear pore complexes (NPCs); nucleoporin; post-translational modifications mRNA export; mRNA quality control; nuclear pore complexes (NPCs); nucleoporin; post-translational modifications
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bonnet, A.; Palancade, B. Regulation of mRNA Trafficking by Nuclear Pore Complexes. Genes 2014, 5, 767-791.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top