Next Article in Journal
Functional Capabilities of the Earliest Peptides and the Emergence of Life
Previous Article in Journal
Genes Involved in the Production of Antimetabolite Toxins by Pseudomonas syringae Pathovars
Article Menu

Export Article

Open AccessArticle
Genes 2011, 2(4), 661-670; doi:10.3390/genes2040661

A Model of DNA Repeat-Assembled Mitotic Chromosomal Skeleton

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-1069, USA
Received: 1 August 2011 / Revised: 15 September 2011 / Accepted: 21 September 2011 / Published: 26 September 2011
View Full-Text   |   Download PDF [238 KB, uploaded 26 September 2011]   |  

Abstract

Despite intensive investigation for decades, the principle of higher-order organization of mitotic chromosomes is unclear. Here, I describe a novel model that emphasizes a critical role of interactions of homologous DNA repeats (repetitive elements; repetitive sequences) in mitotic chromosome architecture. According to the model, DNA repeats are assembled, via repeat interactions (pairing), into compact core structures that govern the arrangement of chromatins in mitotic chromosomes. Tandem repeat assemblies form a chromosomal axis to coordinate chromatins in the longitudinal dimension, while dispersed repeat assemblies form chromosomal nodes around the axis to organize chromatins in the halo. The chromosomal axis and nodes constitute a firm skeleton on which non-skeletal chromatins can be anchored, folded, and supercoiled.
Keywords: repetitive DNA; DNA repeats; mitotic chromosome; chromosomal skeleton; repeat pairing; chromatin repetitive DNA; DNA repeats; mitotic chromosome; chromosomal skeleton; repeat pairing; chromatin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Tang, S.-J. A Model of DNA Repeat-Assembled Mitotic Chromosomal Skeleton. Genes 2011, 2, 661-670.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top