Genes 2010, 1(3), 469-483; doi:10.3390/genes1030469
Article

A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis

email, email, email and * email
Received: 18 October 2010; in revised form: 19 November 2010 / Accepted: 1 December 2010 / Published: 13 December 2010
(This article belongs to the Special Issue Genetics of Mammalian Meiosis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Male spermatogenesis is an essential and complex process necessary to gain totipotency and allow a whole new organism to develop upon fertilization. While single-gene based studies have provided insights into the mechanisms underlying spermatogenesis, detailed global profiling of all the key meiotic stages is required to fully define these processes. Here, by isolating highly enriched mouse meiotic cell populations, we have generated a comprehensive gene expression atlas of mammalian meiosis. Our data define unique signatures for the specific stages of meiosis, including global chromosome X inactivation and reactivation. The data also reveal profound switches in global gene expression at the initiation of pachynema that are reminiscent of the commitment to meiosis observed in budding yeast. Overall, this meiotic atlas provides an exhaustive blueprint and resource for mammalian gametogenesis and meiosis.
Keywords: meiosis; commitment; transcription; dynamic; expression array; mouse; MSCI
PDF Full-text Download PDF Full-Text [709 KB, uploaded 13 December 2010 17:05 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Fallahi, M.; Getun, I.V.; Wu, Z.K.; Bois, P.R. A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis. Genes 2010, 1, 469-483.

AMA Style

Fallahi M, Getun IV, Wu ZK, Bois PR. A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis. Genes. 2010; 1(3):469-483.

Chicago/Turabian Style

Fallahi, Mohammad; Getun, Irina V.; Wu, Zhen K.; Bois, Philippe R.J. 2010. "A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis." Genes 1, no. 3: 469-483.


Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert