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Genes 2010, 1(3), 469-483; doi:10.3390/genes1030469

A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis

Genome Plasticity Laboratory, Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL 33458, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 18 October 2010 / Revised: 19 November 2010 / Accepted: 1 December 2010 / Published: 13 December 2010
(This article belongs to the Special Issue Genetics of Mammalian Meiosis)
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Male spermatogenesis is an essential and complex process necessary to gain totipotency and allow a whole new organism to develop upon fertilization. While single-gene based studies have provided insights into the mechanisms underlying spermatogenesis, detailed global profiling of all the key meiotic stages is required to fully define these processes. Here, by isolating highly enriched mouse meiotic cell populations, we have generated a comprehensive gene expression atlas of mammalian meiosis. Our data define unique signatures for the specific stages of meiosis, including global chromosome X inactivation and reactivation. The data also reveal profound switches in global gene expression at the initiation of pachynema that are reminiscent of the commitment to meiosis observed in budding yeast. Overall, this meiotic atlas provides an exhaustive blueprint and resource for mammalian gametogenesis and meiosis.
Keywords: meiosis; commitment; transcription; dynamic; expression array; mouse; MSCI meiosis; commitment; transcription; dynamic; expression array; mouse; MSCI
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Fallahi, M.; Getun, I.V.; Wu, Z.K.; Bois, P.R. A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis. Genes 2010, 1, 469-483.

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