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Cells 2018, 7(4), 25; https://doi.org/10.3390/cells7040025

Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection

1,2
and
1,2,3,*
1
Institute-Associated Research Group: Cell Adhesion and Cell Polarity, Institute of Medical Biochemistry, ZMBE, University of Münster, Von-Esmarch-Str. 56, D-48149 Münster, Germany
2
Interdisciplinary Clinical Research Center (IZKF), University of Münster, D-48149 Münster, Germany
3
Cells-In-Motion Cluster of Excellence (EXC1003-CiM), University of Münster, D-48149 Münster, Germany
*
Author to whom correspondence should be addressed.
Received: 27 February 2018 / Revised: 21 March 2018 / Accepted: 24 March 2018 / Published: 26 March 2018
(This article belongs to the Special Issue Cell Adhesion Molecules)
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Abstract

Junctional adhesion molecules (JAMs) are cell surface adhesion receptors of the immunoglobulin superfamily. JAMs are involved in a variety of biological processes both in the adult organism but also during development. These include processes such as inflammation, angiogenesis, hemostasis, or epithelial barrier formation, but also developmental processes such as hematopoiesis, germ cell development, and development of the nervous system. Several of these functions of JAMs depend on a physical and functional interaction with integrins. The JAM – integrin interactions in trans regulate cell-cell adhesion, their interactions in cis regulate signaling processes originating at the cell surface. The JAM – integrin interaction can regulate the function of the JAM as well as the function of the integrin. Beyond the physical interaction with integrins, JAMs can regulate integrin function through intracellular signaling indicating an additional level of JAM – integrin cross-talk. In this review, we describe the various levels of the functional interplay between JAMs and integrins and the role of this interplay during different physiological processes. View Full-Text
Keywords: cis-interaction; integrin; junctional adhesion molecule (JAM); JAM-A; trans-interaction; leukocyte adhesion; signaling complex; tetraspanin; tetraspanin-enriched microdomain cis-interaction; integrin; junctional adhesion molecule (JAM); JAM-A; trans-interaction; leukocyte adhesion; signaling complex; tetraspanin; tetraspanin-enriched microdomain
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Kummer, D.; Ebnet, K. Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection. Cells 2018, 7, 25.

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