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Cells 2018, 7(4), 24; https://doi.org/10.3390/cells7040024

Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective

School of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, China
These authors contributed equally to this work.
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Received: 24 January 2018 / Revised: 18 March 2018 / Accepted: 21 March 2018 / Published: 23 March 2018
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Abstract

The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improvement of delivering drugs across the BBB in recent years to treat CNS diseases. In this review, the anatomical and functional structure of the BBB is comprehensively discussed. The mechanisms of BBB penetration are summarized, and the methods and effects on increasing BBB permeability are investigated in detail. It also elaborates on the physical, chemical, biological and nanocarrier aspects to improve drug delivery penetration to the brain and introduces some specific drug delivery effects on BBB permeability. View Full-Text
Keywords: blood–brain barrier; drug delivery system to brain; central nervous system; diseases; permeability improvements blood–brain barrier; drug delivery system to brain; central nervous system; diseases; permeability improvements
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He, Q.; Liu, J.; Liang, J.; Liu, X.; Li, W.; Liu, Z.; Ding, Z.; Tuo, D. Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective. Cells 2018, 7, 24.

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