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Cells 2016, 5(1), 9; doi:10.3390/cells5010009

The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein—TbBILBO1

CNRS, Microbiology Fundamental and Pathogenicity, UMR 5234, F-33000 Bordeaux, France
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Author to whom correspondence should be addressed.
Academic Editors: Gang Dong and William Tsang
Received: 22 December 2015 / Revised: 19 February 2016 / Accepted: 23 February 2016 / Published: 2 March 2016
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
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Abstract

Sub-species of Trypanosoma brucei are the causal agents of human African sleeping sickness and Nagana in domesticated livestock. These pathogens have developed an organelle-like compartment called the flagellar pocket (FP). The FP carries out endo- and exocytosis and is the only structure this parasite has evolved to do so. The FP is essential for parasite viability, making it an interesting structure to evaluate as a drug target, especially since it has an indispensible cytoskeleton component called the flagellar pocket collar (FPC). The FPC is located at the neck of the FP where the flagellum exits the cell. The FPC has a complex architecture and division cycle, but little is known concerning its organization. Recent work has focused on understanding how the FP and the FPC are formed and as a result of these studies an important calcium-binding, polymer-forming protein named TbBILBO1 was identified. Cellular biology analysis of TbBILBO1 has demonstrated its uniqueness as a FPC component and until recently, it was unknown what structural role it played in forming the FPC. This review summarizes the recent data on the polymer forming properties of TbBILBO1 and how these are correlated to the FP cytoskeleton. View Full-Text
Keywords: TbBILBO1; flagellar pocket; flagellar pocket collar; cytoskeleton; flagellum; trypanosome; polymer; neglected tropical diseases TbBILBO1; flagellar pocket; flagellar pocket collar; cytoskeleton; flagellum; trypanosome; polymer; neglected tropical diseases
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Perdomo, D.; Bonhivers, M.; Robinson, D.R. The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein—TbBILBO1. Cells 2016, 5, 9.

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