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Cells 2016, 5(1), 10; doi:10.3390/cells5010010

Hypoxia Induced NF-κB

Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dow street, Dundee DD1 5EH, UK
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Author to whom correspondence should be addressed.
Academic Editor: Ruaidhri Carmody
Received: 28 January 2016 / Revised: 1 March 2016 / Accepted: 3 March 2016 / Published: 8 March 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
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Abstract

As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia. View Full-Text
Keywords: Hypoxia; NF-κB; IKK; HIF-1; PHDs; FIH; TAK; ubiquitin Hypoxia; NF-κB; IKK; HIF-1; PHDs; FIH; TAK; ubiquitin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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D’Ignazio, L.; Rocha, S. Hypoxia Induced NF-κB. Cells 2016, 5, 10.

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