Next Article in Journal
Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells
Previous Article in Journal
Self-Organization of Stem Cell Colonies and of Early Mammalian Embryos: Recent Experiments Shed New Light on the Role of Autonomy vs. External Instructions in Basic Body Plan Development
Previous Article in Special Issue
The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein—TbBILBO1
Article Menu

Export Article

Open AccessReview
Cells 2016, 5(4), 40; doi:10.3390/cells5040040

Airway Epithelial Cell Cilia and Obstructive Lung Disease

1,3
and
1,2,3,*
1
Firestone Research Aerosol Laboratory, Fontbonne Bldg. Room F132, Hamilton, ON L8N 4A6, Canada
2
Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada
3
St. Joseph’s Healthcare, Firestone Institute for Respiratory Health, 50 Charlton Ave East, FIRH Room T2135, Hamilton, ON L8N 4A6, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Gang Dong and William Tsang
Received: 1 August 2016 / Revised: 27 October 2016 / Accepted: 7 November 2016 / Published: 11 November 2016
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
View Full-Text   |   Download PDF [2772 KB, uploaded 11 November 2016]   |  

Abstract

Airway epithelium is the first line of defense against exposure of the airway and lung to various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an important part of the mucociliary transport apparatus. To be effective in transporting secretions out of the lung, the mucociliary transport apparatus must exhibit a cohesive beating of all ciliated epithelial cells that line the upper and lower respiratory tract. Cilia function can be modulated by exposures to endogenous and exogenous factors and by the viscosity of the mucus lining the epithelium. Cilia function is impaired in lung diseases such as COPD and asthma, and pharmacologic agents can modulate cilia function and mucus viscosity. Cilia beating is reduced in COPD, however, more research is needed to determine the structural-functional regulation of ciliary beating via all signaling pathways and how this might relate to the initiation or progression of obstructive lung diseases. Additionally, genotypes and how these can influence phenotypes and epithelial cell cilia function and structure should be taken into consideration in future investigations. View Full-Text
Keywords: epithelium; lung disease; ciliary function; COPD; inflammation; cilia epithelium; lung disease; ciliary function; COPD; inflammation; cilia
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yaghi, A.; Dolovich, M.B. Airway Epithelial Cell Cilia and Obstructive Lung Disease. Cells 2016, 5, 40.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top