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Cells 2015, 4(3), 474-482; doi:10.3390/cells4030474

Ciliary/Flagellar Protein Ubiquitination

Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
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Author to whom correspondence should be addressed.
Academic Editors: William Tsang and Gang Dong
Received: 7 June 2015 / Accepted: 28 August 2015 / Published: 2 September 2015
(This article belongs to the Special Issue Cilia and Flagella: Biogenesis and Function)
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Abstract

Cilia/flagella are conserved eukaryotic organelles that play an important role in the control of cell motility and detection of environmental cues. However, the molecular mechanisms underlying ciliary/flagellar assembly, maintenance, disassembly, and signal transduction are not yet completely understood. Recent studies demonstrated that post-translational modifications (PTMs) such as phosphorylation, methylation, glutamylation, and ubiquitination are involved in these processes. In this mini review, we present a summary of research progress in ciliary/flagellar protein ubiquitination, including the ubiquitin conjugation system identified by proteomics as well as the role of ciliary/flagellar protein ubiquitination in flagellar disassembly, motility, and signal transduction. Moreover, we described putative further research directions in the study of ciliary/flagellar protein ubiquitination. View Full-Text
Keywords: flagella; ubiquitination; post-translational modifications; sperm; primary cilia flagella; ubiquitination; post-translational modifications; sperm; primary cilia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Long, H.; Wang, Q.; Huang, K. Ciliary/Flagellar Protein Ubiquitination. Cells 2015, 4, 474-482.

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