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Cells 2015, 4(2), 218-233; doi:10.3390/cells4020218

Recent Advances in Elucidating the Genetic Mechanisms of Nephrogenesis Using Zebrafish

Department of Biological Sciences, Center for Zebrafish Research, and Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA
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Academic Editor: Christoph Englert
Received: 8 April 2015 / Revised: 19 May 2015 / Accepted: 22 May 2015 / Published: 27 May 2015
(This article belongs to the Special Issue The Kidney: Development, Disease and Regeneration)
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Abstract

The kidney is comprised of working units known as nephrons, which are epithelial tubules that contain a series of specialized cell types organized into a precise pattern of functionally distinct segment domains. There is a limited understanding of the genetic mechanisms that establish these discrete nephron cell types during renal development. The zebrafish embryonic kidney serves as a simplified yet conserved vertebrate model to delineate how nephron segments are patterned from renal progenitors. Here, we provide a concise review of recent advances in this emerging field, and discuss how continued research using zebrafish genetics can be applied to gain insights about nephrogenesis. View Full-Text
Keywords: aPKC; kidney development; hnf1ba/b; mecom; nephron segmentation; renal progenitor; sim1a; tubulogenesis; vertebrate; zebrafish aPKC; kidney development; hnf1ba/b; mecom; nephron segmentation; renal progenitor; sim1a; tubulogenesis; vertebrate; zebrafish
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cheng, C.N.; Verdun, V.A.; Wingert, R.A. Recent Advances in Elucidating the Genetic Mechanisms of Nephrogenesis Using Zebrafish. Cells 2015, 4, 218-233.

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