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Cells 2015, 4(2), 178-201; doi:10.3390/cells4020178

Scavenger Receptor Structure and Function in Health and Disease

1
Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
2
Leeds Vascular Institute, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
3
Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander E. Kalyuzhny
Received: 29 April 2015 / Revised: 14 May 2015 / Accepted: 15 May 2015 / Published: 22 May 2015
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Abstract

Scavenger receptors (SRs) are a ‘superfamily’ of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous proteins and pathogens. New family of SRs and their properties have been identified in recent years, and have now been classified into 10 eukaryote families, defined as Classes A-J. These receptors are classified according to their sequences, although in each class they are further classified based in the variations of the sequence. Their ability to bind a range of ligands is reflected on the biological functions such as clearance of modified lipoproteins and pathogens. SR members regulate pathophysiological states including atherosclerosis, pathogen infections, immune surveillance, and cancer. Here, we review our current understanding of SR structure and function implicated in health and disease. View Full-Text
Keywords: Scavenger receptor; Oxidized LDL particle; Atherosclerosis; Signal transduction Scavenger receptor; Oxidized LDL particle; Atherosclerosis; Signal transduction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zani, I.A.; Stephen, S.L.; Mughal, N.A.; Russell, D.; Homer-Vanniasinkam, S.; Wheatcroft, S.B.; Ponnambalam, S. Scavenger Receptor Structure and Function in Health and Disease. Cells 2015, 4, 178-201.

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