Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
AbstractCardiac Ca2+ cycling and signaling are closely associated with cardiac function. Changes in cellular Ca2+ homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a key role in the regulation of gene expression at the post-transcriptional level and participate in regulating diverse biological processes. The emerging evidence indicates that the expression profiles of miRNAs vary among human diseases, including cardiovascular diseases. Cardiac Ca2+-handling and signaling proteins are also regulated by miRNAs. Given the relationship between cardiac Ca2+ homeostasis and signaling and miRNA, Ca2+-related miRNAs may serve as therapeutic targets during the treatment of heart failure. In this review, we summarize the knowledge currently available regarding the role of Ca2+ in cardiac function, as well as changes in Ca2+ cycling and homeostasis and the handling of these processes by miRNAs during cardiac ischemia-reperfusion injury. View Full-Text
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Choi, E.; Cha, M.-J.; Hwang, K.-C. Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury. Cells 2014, 3, 899-913.
Choi E, Cha M-J, Hwang K-C. Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury. Cells. 2014; 3(3):899-913.Chicago/Turabian Style
Choi, Eunhyun; Cha, Min-Ji; Hwang, Ki-Chul. 2014. "Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury." Cells 3, no. 3: 899-913.