Next Article in Journal
TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision
Next Article in Special Issue
MicroRNAs Regulate Vascular Medial Calcification
Previous Article in Journal / Special Issue
Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease
Article Menu

Export Article

Open AccessReview
Cells 2014, 3(3), 899-913; doi:10.3390/cells3030899

Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury

1
Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Korea
2
Catholic Kwandong University International St. Mary's Hospital, Incheon Metropolitan City 404-834, Korea
*
Author to whom correspondence should be addressed.
Received: 26 May 2014 / Revised: 2 September 2014 / Accepted: 3 September 2014 / Published: 11 September 2014
(This article belongs to the Special Issue MicroRNAs in Cardiovascular Biology and Disease)
View Full-Text   |   Download PDF [1407 KB, uploaded 12 September 2014]   |  

Abstract

Cardiac Ca2+ cycling and signaling are closely associated with cardiac function. Changes in cellular Ca2+ homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a key role in the regulation of gene expression at the post-transcriptional level and participate in regulating diverse biological processes. The emerging evidence indicates that the expression profiles of miRNAs vary among human diseases, including cardiovascular diseases. Cardiac Ca2+-handling and signaling proteins are also regulated by miRNAs. Given the relationship between cardiac Ca2+ homeostasis and signaling and miRNA, Ca2+-related miRNAs may serve as therapeutic targets during the treatment of heart failure. In this review, we summarize the knowledge currently available regarding the role of Ca2+ in cardiac function, as well as changes in Ca2+ cycling and homeostasis and the handling of these processes by miRNAs during cardiac ischemia-reperfusion injury. View Full-Text
Keywords: microRNA; calcium; Ca2+; myocardial ischemia-reperfusion injury; heart microRNA; calcium; Ca2+; myocardial ischemia-reperfusion injury; heart
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Choi, E.; Cha, M.-J.; Hwang, K.-C. Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury. Cells 2014, 3, 899-913.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top