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Cells 2014, 3(3), 883-898; doi:10.3390/cells3030883

Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease

1
Department of Cardiology, Boston Children's Hospital, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA
2
Department of Cardiology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo 160-8582, Japan
3
Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
*
Author to whom correspondence should be addressed.
Received: 10 July 2014 / Revised: 15 August 2014 / Accepted: 15 August 2014 / Published: 22 August 2014
(This article belongs to the Special Issue MicroRNAs in Cardiovascular Biology and Disease)
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Abstract

It has been recognized for decades that proteins, which are encoded by our genome and produced via transcription and translation steps, are building blocks that play vital roles in almost all biological processes. Mutations identified in many protein-coding genes are linked to various human diseases. However, this “protein-centered” dogma has been challenged in recent years with the discovery that the majority of our genome is “non-coding” yet transcribed. Non-coding RNA has become the focus of “next generation” biology. Here, we review the emerging field of non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), and their role in cardiovascular function and disease. View Full-Text
Keywords: cardiac disease; heart development; long non-coding RNAs; microRNAs cardiac disease; heart development; long non-coding RNAs; microRNAs
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kataoka, M.; Wang, D.-Z. Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease. Cells 2014, 3, 883-898.

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