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MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise
AbstractThe short noncoding RNAs, known as microRNAs, are of undisputed importance in cellular signaling during differentiation and development, and during adaptive and maladaptive responses of adult tissues, including those that comprise the heart. Cardiac microRNAs are regulated by hemodynamic overload resulting from exercise or hypertension, in the response of surviving myocardium to myocardial infarction, and in response to environmental or systemic disruptions to homeostasis, such as those arising from diabetes. A large body of work has explored microRNA responses in both physiological and pathological contexts but there is still much to learn about their integrated actions on individual mRNAs and signaling pathways. This review will highlight key studies of microRNA regulation in cardiac stress and suggest possible approaches for more precise identification of microRNA targets, with a view to exploiting the resulting data for therapeutic purposes.
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Matkovich, S.J. MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise. Cells 2014, 3, 778-801.View more citation formats
Matkovich SJ. MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise. Cells. 2014; 3(3):778-801.Chicago/Turabian Style
Matkovich, Scot J. 2014. "MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise." Cells 3, no. 3: 778-801.