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Cells 2014, 3(3), 778-801; doi:10.3390/cells3030778

MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise

Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63130, USA
Received: 12 June 2014 / Revised: 16 July 2014 / Accepted: 23 July 2014 / Published: 5 August 2014
(This article belongs to the Special Issue MicroRNAs in Cardiovascular Biology and Disease)
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Abstract

The short noncoding RNAs, known as microRNAs, are of undisputed importance in cellular signaling during differentiation and development, and during adaptive and maladaptive responses of adult tissues, including those that comprise the heart. Cardiac microRNAs are regulated by hemodynamic overload resulting from exercise or hypertension, in the response of surviving myocardium to myocardial infarction, and in response to environmental or systemic disruptions to homeostasis, such as those arising from diabetes. A large body of work has explored microRNA responses in both physiological and pathological contexts but there is still much to learn about their integrated actions on individual mRNAs and signaling pathways. This review will highlight key studies of microRNA regulation in cardiac stress and suggest possible approaches for more precise identification of microRNA targets, with a view to exploiting the resulting data for therapeutic purposes. View Full-Text
Keywords: RNA-induced silencing complex; microRNA; ribosome; translation; hypertrophy; stress; heart; systems biology RNA-induced silencing complex; microRNA; ribosome; translation; hypertrophy; stress; heart; systems biology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Matkovich, S.J. MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise. Cells 2014, 3, 778-801.

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