Next Article in Journal / Special Issue
microRNAs and Cardiac Cell Fate
Previous Article in Journal
Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer
Previous Article in Special Issue
MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration
Cells 2014, 3(3), 778-801; doi:10.3390/cells3030778
Review

MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise

Received: 12 June 2014; in revised form: 16 July 2014 / Accepted: 23 July 2014 / Published: 5 August 2014
(This article belongs to the Special Issue MicroRNAs in Cardiovascular Biology and Disease)
View Full-Text   |   Download PDF [750 KB, uploaded 5 August 2014]   |   Browse Figures
Abstract: The short noncoding RNAs, known as microRNAs, are of undisputed importance in cellular signaling during differentiation and development, and during adaptive and maladaptive responses of adult tissues, including those that comprise the heart. Cardiac microRNAs are regulated by hemodynamic overload resulting from exercise or hypertension, in the response of surviving myocardium to myocardial infarction, and in response to environmental or systemic disruptions to homeostasis, such as those arising from diabetes. A large body of work has explored microRNA responses in both physiological and pathological contexts but there is still much to learn about their integrated actions on individual mRNAs and signaling pathways. This review will highlight key studies of microRNA regulation in cardiac stress and suggest possible approaches for more precise identification of microRNA targets, with a view to exploiting the resulting data for therapeutic purposes.
Keywords: RNA-induced silencing complex; microRNA; ribosome; translation; hypertrophy; stress; heart; systems biology RNA-induced silencing complex; microRNA; ribosome; translation; hypertrophy; stress; heart; systems biology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Matkovich, S.J. MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise. Cells 2014, 3, 778-801.

AMA Style

Matkovich SJ. MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise. Cells. 2014; 3(3):778-801.

Chicago/Turabian Style

Matkovich, Scot J. 2014. "MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise." Cells 3, no. 3: 778-801.


Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert