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MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration
AbstractCardiac development is an exquisitely regulated process that is sensitive to perturbations in transcriptional activity and gene dosage. Accordingly, congenital heart abnormalities are prevalent worldwide, and are estimated to occur in approximately 1% of live births. Recently, small non-coding RNAs, known as microRNAs, have emerged as critical components of the cardiogenic regulatory network, and have been shown to play numerous roles in the growth, differentiation, and morphogenesis of the developing heart. Moreover, the importance of miRNA function in cardiac development has facilitated the identification of prospective therapeutic targets for patients with congenital and acquired cardiac diseases. Here, we discuss findings attesting to the critical role of miRNAs in cardiogenesis and cardiac regeneration, and present evidence regarding the therapeutic potential of miRNAs for cardiovascular diseases.
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Fuller, A.M.; Qian, L. MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration. Cells 2014, 3, 724-750.View more citation formats
Fuller AM, Qian L. MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration. Cells. 2014; 3(3):724-750.Chicago/Turabian Style
Fuller, Ashley M.; Qian, Li. 2014. "MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration." Cells 3, no. 3: 724-750.
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