Cells 2014, 3(3), 724-750; doi:10.3390/cells3030724
Review

MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration

1,2,3email and 1,2,3,* email
Received: 29 May 2014; in revised form: 25 June 2014 / Accepted: 8 July 2014 / Published: 22 July 2014
(This article belongs to the Special Issue MicroRNAs in Cardiovascular Biology and Disease)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Cardiac development is an exquisitely regulated process that is sensitive to perturbations in transcriptional activity and gene dosage. Accordingly, congenital heart abnormalities are prevalent worldwide, and are estimated to occur in approximately 1% of live births. Recently, small non-coding RNAs, known as microRNAs, have emerged as critical components of the cardiogenic regulatory network, and have been shown to play numerous roles in the growth, differentiation, and morphogenesis of the developing heart. Moreover, the importance of miRNA function in cardiac development has facilitated the identification of prospective therapeutic targets for patients with congenital and acquired cardiac diseases. Here, we discuss findings attesting to the critical role of miRNAs in cardiogenesis and cardiac regeneration, and present evidence regarding the therapeutic potential of miRNAs for cardiovascular diseases.
Keywords: miRNA; cardiovascular development; cardiac regeneration; direct cell reprogramming; differentiation; myosin isoform switching
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MDPI and ACS Style

Fuller, A.M.; Qian, L. MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration. Cells 2014, 3, 724-750.

AMA Style

Fuller AM, Qian L. MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration. Cells. 2014; 3(3):724-750.

Chicago/Turabian Style

Fuller, Ashley M.; Qian, Li. 2014. "MiRiad Roles for MicroRNAs in Cardiac Development and Regeneration." Cells 3, no. 3: 724-750.


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