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MicroRNAs in the Stressed Heart: Sorting the Signal from the Noise
Cells 2014, 3(3), 802-823; doi:10.3390/cells3030802

microRNAs and Cardiac Cell Fate

1 Center for Biomedicine, European Academy of Bolzano/Bozen, Via Galvani 31, I-39100 Bolzano, Italy 2 Centro Cardiologico Monzino, IRCCS, Via Parea 4, I-20138 Milano, Italy
* Author to whom correspondence should be addressed.
Received: 30 May 2014 / Revised: 16 July 2014 / Accepted: 17 July 2014 / Published: 5 August 2014
(This article belongs to the Special Issue MicroRNAs in Cardiovascular Biology and Disease)
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The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their role in controlling the different pathways regulating cell identity and fate determination. In particular, we will focus on the involvement of miRNAs in pluripotency determination and reprogramming, and specifically on cardiac lineage commitment and cell direct transdifferentiation into cardiomyocytes. The identification of cardiac-specific miRNAs and their targets provide new promising insights into the mechanisms that regulate cardiac development, function and dysfunction. Furthermore, due to their contribution in reprogramming, they could offer new opportunities for developing safe and efficient cell-based therapies for cardiovascular disorders.
Keywords: microRNA; pluripotency; cardiomyocytes; cardiac reprogramming; cardiac development microRNA; pluripotency; cardiomyocytes; cardiac reprogramming; cardiac development
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Piubelli, C.; Meraviglia, V.; Pompilio, G.; D'Alessandra, Y.; Colombo, G.I.; Rossini, A. microRNAs and Cardiac Cell Fate. Cells 2014, 3, 802-823.

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