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Cells 2014, 3(2), 627-638; doi:10.3390/cells3020627
The Ufm1 Cascade
Received: 14 March 2014; in revised form: 26 May 2014 / Accepted: 28 May 2014 / Published: 11 June 2014
(This article belongs to the Special Issue Protein Ubiquitination)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The ubiquitin-fold modifier 1 (Ufm1) is a posttranslational modifier that belongs to the ubiquitin-like protein (UBL) family. Ufm1 is present in nearly all eukaryotic organisms, with the exception of fungi. It resembles ubiquitin in its ability to be ligated to other proteins, as well as in the mechanism of ligation. While the Ufm1 cascade has been implicated in endoplasmic reticulum functions and cell cycle control, its biological role still remains poorly understood. In this short review, we summarize the current state of Ufm1 research and its potential role in human diseases, like diabetes, ischemic heart disease and cancer.
Keywords: Ufm1; UBL; ER stress; unfolded protein response