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Cells 2014, 3(2), 258-287; doi:10.3390/cells3020258

Post-Translational Modifications of TRP Channels

Department of Biosensorics, Institute of Physiology, Universität Hohenheim, 70599 Stuttgart, Germany
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Received: 28 February 2014 / Revised: 25 March 2014 / Accepted: 27 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
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Abstract

Transient receptor potential (TRP) channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human. TRP channels exert a multitude of physiological functions ranging from Ca2+ homeostasis in the kidney to pain reception and vision. These channels are activated by a wide range of stimuli and undergo covalent post-translational modifications that affect and modulate their subcellular targeting, their biophysical properties, or channel gating. These modifications include N-linked glycosylation, protein phosphorylation, and covalent attachment of chemicals that reversibly bind to specific cysteine residues. The latter modification represents an unusual activation mechanism of ligand-gated ion channels that is in contrast to the lock-and-key paradigm of receptor activation by its agonists. In this review, we summarize the post-translational modifications identified on TRP channels and, when available, explain their physiological role. View Full-Text
Keywords: post-translational modification; TRP channels; N-linked glycosylation; covalent modification of cysteines; phosphorylation post-translational modification; TRP channels; N-linked glycosylation; covalent modification of cysteines; phosphorylation
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Voolstra, O.; Huber, A. Post-Translational Modifications of TRP Channels. Cells 2014, 3, 258-287.

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