Cells 2014, 3(2), 288-303; doi:10.3390/cells3020288
Review

The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity

1,* email and 2email
Received: 28 February 2014; in revised form: 29 March 2014 / Accepted: 2 April 2014 / Published: 9 April 2014
(This article belongs to the Special Issue Transient Receptor Potential (TRP) Channels)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an increase in intracellular free Ca2+ concentration. Thus, activation of TRPC channels could be a common downstream event of many signaling pathways that contribute to seizure and excitotoxicity, such as N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ influx, or metabotropic glutamate receptor activation. Recent studies with genetic ablation of various TRPC family members have demonstrated that TRPC channels, in particular heteromeric TRPC1/4 channels and homomeric TRPC5 channels, play a critical role in both pilocarpine-induced acute seizures and neuronal cell death. However, exact underlying mechanisms remain to be fully elucidated, and selective TRPC modulators and antibodies with better specificity are urgently needed for future research.
Keywords: canonical transient receptor potential channels; metabotropic glutamate receptors; epileptiform burst firing; seizure; excitotoxicity
PDF Full-text Download PDF Full-Text [658 KB, uploaded 9 April 2014 15:57 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Zheng, F.; Phelan, K.D. The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity. Cells 2014, 3, 288-303.

AMA Style

Zheng F, Phelan KD. The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity. Cells. 2014; 3(2):288-303.

Chicago/Turabian Style

Zheng, Fang; Phelan, Kevin D. 2014. "The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity." Cells 3, no. 2: 288-303.


Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert