Next Article in Journal
Pharmacological Profiles of Oligomerized μ-Opioid Receptors
Next Article in Special Issue
Macroscopic Quantum-Type Potentials in Theoretical Systems Biology
Previous Article in Journal
Pericytes, Mesenchymal Stem Cells and the Wound Healing Process
Previous Article in Special Issue
An Enhanced ELISPOT Assay for Sensitive Detection of Antigen-Specific T Cell Responses to Borrelia burgdorferi
Article Menu

Export Article

Open AccessReview
Cells 2013, 2(4), 635-688; doi:10.3390/cells2040635

Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering

Laborotary of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua University, HsinChu 30013, Taiwan
*
Author to whom correspondence should be addressed.
Received: 16 April 2013 / Revised: 12 September 2013 / Accepted: 19 September 2013 / Published: 11 October 2013
(This article belongs to the Special Issue Feature Papers 2013)
View Full-Text   |   Download PDF [3105 KB, uploaded 11 October 2013]   |  

Abstract

Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived from insight into: (i) system structure and the mechanism of biological networks such as gene regulation, protein interactions, signaling, and metabolic pathways; (ii) system dynamics of biological networks, which provides an understanding of stability, robustness, and transduction ability through system identification, and through system analysis methods; (iii) system control methods at different levels of biological networks, which provide an understanding of systematic mechanisms to robustly control system states, minimize malfunctions, and provide potential therapeutic targets in disease treatment; (iv) systematic design methods for the modification and construction of biological networks with desired behaviors, which provide system design principles and system simulations for synthetic biology designs and systems metabolic engineering. This review describes current developments in systems biology, systems synthetic biology, and systems metabolic engineering for engineering and biology researchers. We also discuss challenges and future prospects for systems biology and the concept of systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering. View Full-Text
Keywords: systems biology; bioinformatics; systems synthetic biology; systems metabolic engineering systems biology; bioinformatics; systems synthetic biology; systems metabolic engineering
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, B.-S.; Wu, C.-C. Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering. Cells 2013, 2, 635-688.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top