Pharmacological Profiles of Oligomerized μ-Opioid Receptors
AbstractOpioids are widely prescribed pain relievers with multiple side effects and potential complications. They produce analgesia via G-protein-protein coupled receptors: μ-, δ-, κ-opioid and opioid receptor-like 1 receptors. Bivalent ligands targeted to the oligomerized opioid receptors might be the key to developing analgesics without undesired side effects and obtaining effective treatment for opioid addicts. In this review we will update the biological effects of μ-opioids on homo- or hetero-oligomerized μ-opioid receptor and discuss potential mechanisms through which bivalent ligands exert beneficial effects, including adenylate cyclase regulation and receptor-mediated signaling pathways. View Full-Text
Share & Cite This Article
Lee, C.W.-S.; Ho, I.-K. Pharmacological Profiles of Oligomerized μ-Opioid Receptors. Cells 2013, 2, 689-714.
Lee CW-S, Ho I-K. Pharmacological Profiles of Oligomerized μ-Opioid Receptors. Cells. 2013; 2(4):689-714.Chicago/Turabian Style
Lee, Cynthia W.-S.; Ho, Ing-Kang. 2013. "Pharmacological Profiles of Oligomerized μ-Opioid Receptors." Cells 2, no. 4: 689-714.