Cells 2013, 2(3), 574-590; doi:10.3390/cells2030574
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Interorganellar Membrane Microdomains: Dynamic Platforms in the Control of Calcium Signaling and Apoptosis

Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
* Author to whom correspondence should be addressed.
Received: 21 June 2013; in revised form: 23 July 2013 / Accepted: 26 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue Apoptosis)
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Abstract: The dynamic interplay among intracellular organelles occurs at specific membrane tethering sites, where two organellar membranes come in close apposition but do not fuse. Such membrane microdomains allow for rapid and efficient interorganelle communication that contributes to the maintenance of cell physiology. Pathological conditions that interfere with the proper composition, number, and physical vicinity of the apposing membranes initiate a cascade of events resulting in cell death. Membrane contact sites have now been identified that tether the extensive network of the endoplasmic reticulum (ER) membranes with the mitochondria, the plasma membrane (PM), the Golgi and the endosomes/lysosomes. Thus far, the most extensively studied are the MAMs, or mitochondria associated ER membranes, and the ER-PM junctions that share functional properties and crosstalk to one another. Specific molecular components that define these microdomains have been shown to promote the interaction in trans between these intracellular compartments and the transfer or exchange of Ca2+ ions, lipids, and metabolic signaling molecules that determine the fate of the cell.
Keywords: interorganellar membrane microdomains; MAMs; ER-PM junctions; GM1-ganglioside; Ca2+ signaling; apoptosis

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MDPI and ACS Style

Annunziata, I.; d'Azzo, A. Interorganellar Membrane Microdomains: Dynamic Platforms in the Control of Calcium Signaling and Apoptosis. Cells 2013, 2, 574-590.

AMA Style

Annunziata I, d'Azzo A. Interorganellar Membrane Microdomains: Dynamic Platforms in the Control of Calcium Signaling and Apoptosis. Cells. 2013; 2(3):574-590.

Chicago/Turabian Style

Annunziata, Ida; d'Azzo, Alessandra. 2013. "Interorganellar Membrane Microdomains: Dynamic Platforms in the Control of Calcium Signaling and Apoptosis." Cells 2, no. 3: 574-590.

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