Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Cells 2012, 1(4), 994-1009; doi:10.3390/cells1040994
Review

Human Stem Cells and Articular Cartilage Regeneration

,
 and *
Received: 3 September 2012; in revised form: 15 October 2012 / Accepted: 24 October 2012 / Published: 5 November 2012
(This article belongs to the Special Issue Tissue and Organ Regeneration)
View Full-Text   |   Download PDF [167 KB, uploaded 5 November 2012]
Abstract: The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells, scaffolds and signals, including morphogens and growth factors. Stem cells, as a source of cells for articular cartilage regeneration, are a critical factor for articular cartilage regeneration. This is because articular cartilage tissue has a low cell turnover and does not heal spontaneously. Adult stem cells have been isolated from various tissues, such as bone marrow, adipose, synovial tissue, muscle and periosteum. Signals of the transforming growth factor beta superfamily play critical roles in chondrogenesis. However, adult stem cells derived from various tissues tend to differ in their chondrogenic potential. Pluripotent stem cells have unlimited proliferative capacity compared to adult stem cells. Chondrogenesis from embryonic stem (ES) cells has been studied for more than a decade. However, establishment of ES cells requires embryos and leads to ethical issues for clinical applications. Induced pluripotent stem (iPS) cells are generated by cellular reprogramming of adult cells by transcription factors. Although iPS cells have chondrogenic potential, optimization, generation and differentiation toward articular chondrocytes are currently under intense investigation.
Keywords: stem cells; articular cartilage; growth factors stem cells; articular cartilage; growth factors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Inui, A.; Iwakura, T.; Reddi, A.H. Human Stem Cells and Articular Cartilage Regeneration. Cells 2012, 1, 994-1009.

AMA Style

Inui A, Iwakura T, Reddi AH. Human Stem Cells and Articular Cartilage Regeneration. Cells. 2012; 1(4):994-1009.

Chicago/Turabian Style

Inui, Atsuyuki; Iwakura, Takashi; Reddi, A. H. 2012. "Human Stem Cells and Articular Cartilage Regeneration." Cells 1, no. 4: 994-1009.


Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert