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Cells 2012, 1(3), 325-345; doi:10.3390/cells1030325
Review

Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies

*  and *
Received: 4 May 2012; in revised form: 18 June 2012 / Accepted: 13 July 2012 / Published: 26 July 2012
(This article belongs to the Special Issue Autophagy)
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Abstract: Skeletal muscles are the agent of motion and one of the most important tissues responsible for the control of metabolism. The maintenance of muscle homeostasis is finely regulated by the balance between catabolic and anabolic process. Macroautophagy (or autophagy) is a catabolic process that provides the degradation of protein aggregation and damaged organelles through the fusion between autophagosomes and lysosomes. Proper regulation of the autophagy flux is fundamental for the homeostasis of skeletal muscles during physiological situations and in response to stress. Defective as well as excessive autophagy is harmful for muscle health and has a pathogenic role in several forms of muscle diseases. This review will focus on the role of autophagy in muscle homeostasis and diseases.
Keywords: autophagy; skeletal muscle; dystrophy autophagy; skeletal muscle; dystrophy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Grumati, P.; Bonaldo, P. Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies. Cells 2012, 1, 325-345.

AMA Style

Grumati P, Bonaldo P. Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies. Cells. 2012; 1(3):325-345.

Chicago/Turabian Style

Grumati, Paolo; Bonaldo, Paolo. 2012. "Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies." Cells 1, no. 3: 325-345.



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