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Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies
Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, Padova 35131, Italy
* Authors to whom correspondence should be addressed.
Received: 4 May 2012; in revised form: 18 June 2012 / Accepted: 13 July 2012 / Published: 26 July 2012
(This article belongs to the Special Issue Autophagy
Abstract: Skeletal muscles are the agent of motion and one of the most important tissues responsible for the control of metabolism. The maintenance of muscle homeostasis is finely regulated by the balance between catabolic and anabolic process. Macroautophagy (or autophagy) is a catabolic process that provides the degradation of protein aggregation and damaged organelles through the fusion between autophagosomes and lysosomes. Proper regulation of the autophagy flux is fundamental for the homeostasis of skeletal muscles during physiological situations and in response to stress. Defective as well as excessive autophagy is harmful for muscle health and has a pathogenic role in several forms of muscle diseases. This review will focus on the role of autophagy in muscle homeostasis and diseases.
Keywords: autophagy; skeletal muscle; dystrophy
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Grumati, P.; Bonaldo, P. Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies. Cells 2012, 1, 325-345.
Grumati P, Bonaldo P. Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies. Cells. 2012; 1(3):325-345.
Grumati, Paolo; Bonaldo, Paolo. 2012. "Autophagy in Skeletal Muscle Homeostasis and in Muscular Dystrophies." Cells 1, no. 3: 325-345.