Cells 2012, 1(2), 100-110; doi:10.3390/cells1020100
Review

Role of ELISPOT Assays in Risk Assessment Pre- and Post-Kidney Transplantation

* email and email
Received: 23 March 2012; in revised form: 30 April 2012 / Accepted: 7 May 2012 / Published: 10 May 2012
(This article belongs to the Special Issue ELISPOT Research)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Immunologic risk in kidney transplantation is typically minimized by avoiding, or at least limiting, the potential of donor specific humoral responses by testing for the presence of donor-specific antibodies (DSA). Additionally, selecting donor and recipient pairs with the least number of human leukocyte antigen (HLA) mismatches has been shown to play a role in transplant outcome. However, numerous other factors may play a role in the success of transplant outcome and patient health. Specifically, the use of T-cell allospecific ELISPOT assays have helped elucidate the role of pre-formed cellular responses as additional factors in post-transplant outcome. In this review, we will evaluate numerous uses of ELISPOT assays to assess the pre- and post-transplant immunologic risk of rejection episodes, graft survival and even viral susceptibility as well as the utility of ELISPOT assays in monitoring tolerance and withdrawal of immunosuppressive medications following kidney transplantation.
Keywords: ELISPOT; kidney; transplant; risk assessment
PDF Full-text Download PDF Full-Text [165 KB, uploaded 10 May 2012 08:51 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Zitzner, J.R.; Tambur, A.R. Role of ELISPOT Assays in Risk Assessment Pre- and Post-Kidney Transplantation. Cells 2012, 1, 100-110.

AMA Style

Zitzner JR, Tambur AR. Role of ELISPOT Assays in Risk Assessment Pre- and Post-Kidney Transplantation. Cells. 2012; 1(2):100-110.

Chicago/Turabian Style

Zitzner, Jennifer R.; Tambur, Anat R. 2012. "Role of ELISPOT Assays in Risk Assessment Pre- and Post-Kidney Transplantation." Cells 1, no. 2: 100-110.

Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert