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Polymers 2017, 9(9), 416; https://doi.org/10.3390/polym9090416

Fabrication of Multi-Layered Lidocaine and Epinephrine-Eluting PLGA/Collagen Nanofibers: In Vitro and In Vivo Study

1
Department of Periodontics, Division of Dentistry, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan
2
Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, Taiwan
3
Department of Physiology and Pharmacology, Chang Gung University, Tao-Yuan 33302, Taiwan
4
Department of Pathology, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan
5
Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Tao-Yuan 33305, Taiwan
*
Author to whom correspondence should be addressed.
Received: 9 August 2017 / Revised: 30 August 2017 / Accepted: 3 September 2017 / Published: 5 September 2017
(This article belongs to the Special Issue Processing-Structure-Properties Relationships in Polymers)
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Abstract

This study developed multi-layered lidocaine- and epinephrine-eluting biodegradable poly[(d,l)-lactide-co-glyco lide] (PLGA)/collagen nanofibers. An electrospinning technique was employed to fabricate the multi-layer biodegradable drug-eluting nanofibers. After fabrication, the nanofibrous membranes were characterized. The drug release characteristics were also investigated. In addition, the in vivo efficacy of nanofibers for pain relief and hemostasis in palatal oral wounds of rabbits were evaluated. Histological examinations were also completed. The experimental results suggested that all nanofibers exhibited good biocompatibility and eluted effective levels of lidocaine and epinephrine at the initial stages of wound recovery. View Full-Text
Keywords: biodegradable nanofibers; PLGA; collagen; epinephrine; lidocaine biodegradable nanofibers; PLGA; collagen; epinephrine; lidocaine
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Lee, F.-Y.; Lee, D.; Lee, T.-C.; Chen, J.-K.; Wu, R.-C.; Liu, K.-C.; Liu, S.-J. Fabrication of Multi-Layered Lidocaine and Epinephrine-Eluting PLGA/Collagen Nanofibers: In Vitro and In Vivo Study. Polymers 2017, 9, 416.

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