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Polymers 2017, 9(5), 154; doi:10.3390/polym9050154

Surface Patterning of Gold Nanoparticles on PEG-Based Hydrogels to Control Cell Adhesion

1
Nanopatterned Biomaterials, Technische Universität Berlin, Sekr. TC 1, Strasse des 17. Juni 124, Berlin 10623, Germany
2
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Helmut Schlaad
Received: 31 March 2017 / Revised: 18 April 2017 / Accepted: 21 April 2017 / Published: 26 April 2017
(This article belongs to the Special Issue Bio-inspired and Bio-based Polymers)
View Full-Text   |   Download PDF [7081 KB, uploaded 26 April 2017]   |  

Abstract

We report on a versatile and easy approach to micro-pattern gold nanoparticles (Au NPs) on 8-arm poly(ethylene glycol)-vinyl sulfone thiol (8PEG-VS-SH) hydrogels, and the application of these patterned Au NPs stripes in controlling cell adhesion. Firstly, the Au NPs were patterned on silicon wafers, and then they were transferred onto reactive, multifunctional 8PEG-VS-SH hydrogels. The patterned, micrometer-sized Au NPs stripes with variable spacings ranging from 20 μm to 50 μm were created by our recently developed micro-contact deprinting method. For this micro-contact deprinting approach, four different PEG-based stamp materials have been tested and it was found that the triblock copolymer PEG-PPG-PEG-(3BC) stamp established the best transfer efficiency and has been used in the ongoing work. After the successful creation of micro-patterns of Au NPs stripes on silicon, the patterns can be transferred conveniently and accurately to 8PEG-VS-SH hydrogel films. Subsequently these Au NPs patterns on 8PEG-VS-SH hydrogels have been investigated in cell culture with murine fibroblasts (L-929). The cells have been observed to adhere to and spread on those nano-patterned micro-lines in a remarkably selective and ordered manner. View Full-Text
Keywords: poly(ethylene glycol) hydrogels; gold nanoparticles; micro-contact deprinting; pattern transfer; cell adhesion poly(ethylene glycol) hydrogels; gold nanoparticles; micro-contact deprinting; pattern transfer; cell adhesion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ren, F.; Yesildag, C.; Zhang, Z.; Lensen, M.C. Surface Patterning of Gold Nanoparticles on PEG-Based Hydrogels to Control Cell Adhesion. Polymers 2017, 9, 154.

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