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Polymers 2016, 8(7), 252; doi:10.3390/polym8070252

Thermo-Responsive Polyurethane Hydrogels Based on Poly(ε-caprolactone) Diol and Amphiphilic Polylactide-Poly(Ethylene Glycol) Block Copolymers

1
Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan
2
Institut Europeen des Membranes, UMR CNRS 5635, Universite de Montpellier, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
*
Author to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Received: 1 May 2016 / Revised: 26 June 2016 / Accepted: 29 June 2016 / Published: 5 July 2016
(This article belongs to the Special Issue Biodegradable Polymers)
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Abstract

Waterborne polyurethane (PU) based on poly(ε-caprolactone) (PCL) diol and an amphiphilic polylactide-poly(ethylene glycol) (PLA-PEG) diblock copolymer was synthesized. The molar ratio of PCL/PLA-PEG was 9:1 with different PLA chain lengths. The PU nanoparticles were characterized by dynamic light scattering (DLS), small angle X-ray scattering (SAXS) and rheological analysis. The water contact angle measurement, infrared spectroscopy, wide angle X-ray scattering (WAXS), thermal and mechanical analyses were conducted on PU films. Significant changes in physio-chemical properties were observed for PUs containing 10 mol % of amphiphilic blocks. The water contact angle was reduced to 12°–13°, and the degree of crystallinity was 5%–10%. The PU dispersions underwent sol-gel transition upon the temperature rise to 37 °C. The gelation time increased as the PLA chain length increased. In addition, the fractal dimension of each gel was close to that of a percolation cluster. Moreover, PU4 with a solid content of 26% could support the proliferation of human mesenchymal stem cells (hMSCs). Therefore, thermo-responsive hydrogels with tunable properties are promising injectable materials for cell or drug delivery. View Full-Text
Keywords: waterborne polyurethane; poly(ε-caprolactone); polylactide–poly(ethylene glycol); small angle X-ray scattering (SAXS); hydrogel waterborne polyurethane; poly(ε-caprolactone); polylactide–poly(ethylene glycol); small angle X-ray scattering (SAXS); hydrogel
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hsu, S.-H.; Chen, C.-W.; Hung, K.-C.; Tsai, Y.-C.; Li, S. Thermo-Responsive Polyurethane Hydrogels Based on Poly(ε-caprolactone) Diol and Amphiphilic Polylactide-Poly(Ethylene Glycol) Block Copolymers. Polymers 2016, 8, 252.

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