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Polymers 2016, 8(5), 192; doi:10.3390/polym8050192

Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs

1
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany
2
Laboratoire de Photochimie et d’Ingénierie Macromoléculaires, Université de Haute Alsace, 3 rue Alfred Werner, 68093 Mulhouse Cedex, France
*
Author to whom correspondence should be addressed.
Academic Editors: André Laschewsky and Sebastien Lecommandoux
Received: 26 February 2016 / Revised: 14 April 2016 / Accepted: 3 May 2016 / Published: 14 May 2016
(This article belongs to the Special Issue Polymers for Aqueous Media)

Abstract

A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was investigated by NMR spectroscopy. The new CMS nanocarrier can transport one molecule of dexamethasone and degrades within five days at a skin temperature of 32 °C to biocompatible fragments. View Full-Text
Keywords: nanocarrier; biodegradable; polyester nanocarrier; biodegradable; polyester
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Walker, K.A.; Stumbé, J.-F.; Haag, R. Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs. Polymers 2016, 8, 192.

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