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Polymers 2016, 8(11), 380; doi:10.3390/polym8110380

Recent Advances in Dual Temperature Responsive Block Copolymers and Their Potential as Biomedical Applications

1
Department of Materials and Life Science, Shizuoka Institute of Science and Technology, 2200-2 Toyosawa, Fukuroi, Shizuoka 437-8555, Japan
2
International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
3
Graduate School of Industrial Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika, Tokyo 125-8585, Japan
4
Department of Materials Engineering, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan
5
College of Science and Technology, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
6
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada
*
Authors to whom correspondence should be addressed.
Academic Editor: Shiyong Liu
Received: 6 September 2016 / Revised: 4 October 2016 / Accepted: 8 October 2016 / Published: 27 October 2016
View Full-Text   |   Download PDF [6199 KB, uploaded 27 October 2016]   |  

Abstract

The development of stimuli responsive polymers has progressed significantly with novel preparation techniques, which has allowed access to new materials with unique properties. Dual thermoresponsive (double temperature responsive) block copolymers are particularly of interest as their properties can change depending on the lower critical solution temperature (LCST) or upper critical solution temperature (UCST) of each segment. For instance, these block copolymers can change from being hydrophilic, to amphiphilic or to hydrophobic simply by changing the solution temperature without any additional chemicals and the block copolymers can change from being fully solubilized to self-assembled structures to macroscopic aggregation/precipitation. Based on the unique solution properties, these dual thermo-responsive block copolymers are expected to be suitable for biomedical applications. This review is divided into three parts; LCST-LCST types of block copolymers, UCST-LCST types of block copolymers, and their potential as biomedical applications. View Full-Text
Keywords: dual thermoresponsive block copolymers; smart polymers; biomaterials dual thermoresponsive block copolymers; smart polymers; biomaterials
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Kotsuchibashi, Y.; Ebara, M.; Aoyagi, T.; Narain, R. Recent Advances in Dual Temperature Responsive Block Copolymers and Their Potential as Biomedical Applications. Polymers 2016, 8, 380.

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