Synthesis and Biological Evaluation of New Imine- and Amino-Chitosan Derivatives
AbstractN-substituted chitosan derivatives were synthesized through condensation with a number of selected aryl and heteroaryl aldehydes. The synthesis of the amino-derivatives has been carried out by reductive amination with sodium borohydride as reducing agent. Their structures were characterized by (FT-IR, 1HNMR, and XRD). The antimicrobial activity of Chitosan Schiff’s base (CSB) derivatives were investigated against four types of bacteria and two crop-threatening pathogenic fungi, and the results indicated that the antibacterial and antifungal activities of the investigated derivatives are very promising. Additionally, different concentrations of the triazolo-Schiff’s base derivative 3c were used for cytotoxicity screening against Human Breast Adenocarcinoma Cells (MCF-7), Human Colon Carcinoma Cells (HCT-116), and Human Hepatocellular Liver Carcinoma Cells (HepG-2), and the obtained data revealed that the examined compounds have an excellent cell growth inhibitory effects on the cell lines as compared to standard. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Abdelwahab, H.E.; Hassan, S.Y.; Yacout, G.A.; Mostafa, M.A.; El Sadek, M.M. Synthesis and Biological Evaluation of New Imine- and Amino-Chitosan Derivatives. Polymers 2015, 7, 2690-2700.
Abdelwahab HE, Hassan SY, Yacout GA, Mostafa MA, El Sadek MM. Synthesis and Biological Evaluation of New Imine- and Amino-Chitosan Derivatives. Polymers. 2015; 7(12):2690-2700.Chicago/Turabian Style
Abdelwahab, Huda E.; Hassan, Seham Y.; Yacout, Galila A.; Mostafa, Mohamed A.; El Sadek, Mohamed M. 2015. "Synthesis and Biological Evaluation of New Imine- and Amino-Chitosan Derivatives." Polymers 7, no. 12: 2690-2700.