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Polymers 2015, 7(12), 2690-2700; doi:10.3390/polym7121532

Synthesis and Biological Evaluation of New Imine- and Amino-Chitosan Derivatives

1
Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt
2
Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Jung Kwon (John) Oh
Received: 17 September 2015 / Revised: 22 October 2015 / Accepted: 28 October 2015 / Published: 21 December 2015
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Abstract

N-substituted chitosan derivatives were synthesized through condensation with a number of selected aryl and heteroaryl aldehydes. The synthesis of the amino-derivatives has been carried out by reductive amination with sodium borohydride as reducing agent. Their structures were characterized by (FT-IR, 1HNMR, and XRD). The antimicrobial activity of Chitosan Schiff’s base (CSB) derivatives were investigated against four types of bacteria and two crop-threatening pathogenic fungi, and the results indicated that the antibacterial and antifungal activities of the investigated derivatives are very promising. Additionally, different concentrations of the triazolo-Schiff’s base derivative 3c were used for cytotoxicity screening against Human Breast Adenocarcinoma Cells (MCF-7), Human Colon Carcinoma Cells (HCT-116), and Human Hepatocellular Liver Carcinoma Cells (HepG-2), and the obtained data revealed that the examined compounds have an excellent cell growth inhibitory effects on the cell lines as compared to standard. View Full-Text
Keywords: chitosan; imine; antimicrobial chitosan; imine; antimicrobial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Abdelwahab, H.E.; Hassan, S.Y.; Yacout, G.A.; Mostafa, M.A.; El Sadek, M.M. Synthesis and Biological Evaluation of New Imine- and Amino-Chitosan Derivatives. Polymers 2015, 7, 2690-2700.

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