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Coarse-Grained Models for Protein-Cell Membrane Interactions
Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia,PA 19104, USA
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
* Author to whom correspondence should be addressed.
Received: 26 April 2013; in revised form: 20 June 2013 / Accepted: 20 June 2013 / Published: 2 July 2013
Abstract: The physiological properties of biological soft matter are the product of collective interactions, which span many time and length scales. Recent computational modeling efforts have helped illuminate experiments that characterize the ways in which proteins modulate membrane physics. Linking these models across time and length scales in a multiscale model explains how atomistic information propagates to larger scales. This paper reviews continuum modeling and coarse-grained molecular dynamics methods, which connect atomistic simulations and single-molecule experiments with the observed microscopic or mesoscale properties of soft-matter systems essential to our understanding of cells, particularly those involved in sculpting and remodeling cell membranes.
Keywords: molecular dynamics; coarse-grained model; membrane proteins
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Bradley, R.; Radhakrishnan, R. Coarse-Grained Models for Protein-Cell Membrane Interactions. Polymers 2013, 5, 890-936.
Bradley R, Radhakrishnan R. Coarse-Grained Models for Protein-Cell Membrane Interactions. Polymers. 2013; 5(3):890-936.
Bradley, Ryan; Radhakrishnan, Ravi. 2013. "Coarse-Grained Models for Protein-Cell Membrane Interactions." Polymers 5, no. 3: 890-936.