Polymers 2013, 5(3), 1102-1114; doi:10.3390/polym5031102
Article

Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles

1email, 1,2email, 1,3email, 1,2,* email and 1,* email
Received: 1 July 2013; in revised form: 5 August 2013 / Accepted: 29 August 2013 / Published: 6 September 2013
(This article belongs to the Special Issue Supramolecular Chemistry and Self-Assembly)
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Abstract: Hybrid phospholipid/block copolymer vesicles, in which the polymeric membrane is blended with phospholipids, display interesting self-assembly behavior, incorporating the robustness and chemical versatility of polymersomes with the softness and biocompatibility of liposomes. Such structures can be conveniently characterized by preparing giant unilamellar vesicles (GUVs) via electroformation. Here, we are interested in exploring the self-assembly and properties of the analogous nanoscale hybrid vesicles (ca. 100 nm in diameter) of the same composition prepared by film-hydration and extrusion. We show that the self-assembly and content-release behavior of nanoscale polybutadiene-b-poly(ethylene oxide) (PB-PEO)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) hybrid phospholipid/block copolymer vesicles can be tuned by the mixing ratio of the amphiphiles. In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.
Keywords: polymersomes; hybrid vesicles; self-assembly; drug-delivery; soft matter
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lim, S.K.; de Hoog, H.-P.; Parikh, A.N.; Nallani, M.; Liedberg, B. Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles. Polymers 2013, 5, 1102-1114.

AMA Style

Lim SK, de Hoog H-P, Parikh AN, Nallani M, Liedberg B. Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles. Polymers. 2013; 5(3):1102-1114.

Chicago/Turabian Style

Lim, Seng K.; de Hoog, Hans-Peter; Parikh, Atul N.; Nallani, Madhavan; Liedberg, Bo. 2013. "Hybrid, Nanoscale Phospholipid/Block Copolymer Vesicles." Polymers 5, no. 3: 1102-1114.


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