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DNA-Promoted Auto-Assembly of Gold Nanoparticles: Effect of the DNA Sequence on the Stability of the Assemblies
Engineering of Molecular NanoSystems, Ecole polytechnique de Bruxelles, CP 165/64, Université libre de Bruxelles, 50 av. F.D. Roosevelt, Brussels 1050, Belgium
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Received: 26 June 2013; in revised form: 12 July 2013 / Accepted: 15 July 2013 / Published: 22 July 2013
Abstract: The use of deoxyribonucleic acid (DNA) oligonucleotides has proven to be a powerful and versatile strategy to assemble nanomaterials into two (2D) and three-dimensional (3D) superlattices. With the aim of contributing to the elucidation of the factors that affect the stability of this type of superlattices, the assembly of gold nanoparticles grafted with different DNA oligonucleotides was characterized by UV-Vis absorption spectroscopy as a function of temperature. After establishing an appropriate methodology the effect of (i) the length of the grafted oligonucleotides; (ii) the length of their complementary parts and also of (iii) the simultaneous grafting of different oligonucleotides was investigated. Our results indicate that the electrostatic repulsion between the particles and the cooperativity of the assembly process play crucial roles in the stability of the assemblies while the grafting density of the oligonucleotide strands seems to have little influence.
Keywords: gold nanoparticles; oligonucleotides; superlattices; thermal stability; UV-Vis absorption spectroscopy
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MDPI and ACS Style
Doyen, M.; Bartik, K.; Bruylants, G. DNA-Promoted Auto-Assembly of Gold Nanoparticles: Effect of the DNA Sequence on the Stability of the Assemblies. Polymers 2013, 5, 1041-1055.
Doyen M, Bartik K, Bruylants G. DNA-Promoted Auto-Assembly of Gold Nanoparticles: Effect of the DNA Sequence on the Stability of the Assemblies. Polymers. 2013; 5(3):1041-1055.
Doyen, Matthieu; Bartik, Kristin; Bruylants, Gilles. 2013. "DNA-Promoted Auto-Assembly of Gold Nanoparticles: Effect of the DNA Sequence on the Stability of the Assemblies." Polymers 5, no. 3: 1041-1055.