Polymers 2013, 5(1), 161-187; doi:10.3390/polym5010161

Polyphosphazenes: Multifunctional, Biodegradable Vehicles for Drug and Gene Delivery

* email and email
Received: 4 January 2013; in revised form: 1 February 2013 / Accepted: 4 February 2013 / Published: 8 February 2013
(This article belongs to the Special Issue Bioconjugates/Biohybrid Polymers)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Poly[(organo)phosphazenes] are a unique class of extremely versatile polymers with a range of applications including tissue engineering and drug delivery, as hydrogels, shape memory polymers and as stimuli responsive materials. This review aims to divulge the basic principles of designing polyphosphazenes for drug and gene delivery and portray the huge potential of these extremely versatile materials for such applications. Polyphosphazenes offer a number of distinct advantages as carriers for bioconjugates; alongside their completely degradable backbone, to non-toxic degradation products, they possess an inherently and uniquely high functionality and, thanks to recent advances in their polymer chemistry, can be prepared with controlled molecular weights and narrow polydispersities, as well as self-assembled supra-molecular structures. Importantly, the rate of degradation/hydrolysis of the polymers can be carefully tuned to suit the desired application. In this review we detail the recent developments in the chemistry of polyphosphazenes, relevant to drug and gene delivery and describe recent investigations into their application in this field.
Keywords: polyphosphazenes; biodegradable polymers; drug delivery; gene delivery; polymer therapeutics; nanomedicines
PDF Full-text Download PDF Full-Text [482 KB, uploaded 8 February 2013 09:04 CET]

Export to BibTeX |

MDPI and ACS Style

Teasdale, I.; Brüggemann, O. Polyphosphazenes: Multifunctional, Biodegradable Vehicles for Drug and Gene Delivery. Polymers 2013, 5, 161-187.

AMA Style

Teasdale I, Brüggemann O. Polyphosphazenes: Multifunctional, Biodegradable Vehicles for Drug and Gene Delivery. Polymers. 2013; 5(1):161-187.

Chicago/Turabian Style

Teasdale, Ian; Brüggemann, Oliver. 2013. "Polyphosphazenes: Multifunctional, Biodegradable Vehicles for Drug and Gene Delivery." Polymers 5, no. 1: 161-187.

Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert